The setting is the city of Elantris and the surrounding suburbs. There’s a force in Arelon known as the Dor that randomly chooses people and grants them divine powers. Elantris was once the city of the gods, where anyone who was ‘chosen’ went to live. Ten years ago, the Elantrians lost their powers and caught a terrible disease instead. From that point on, Elantris became a prison city/contamination zone for any who caught that disease, for the Dor continues to choose people and curse them.

The book follows the experiences of three people as they interact with the people of Elantris. Raoden, a prince, catches the disease in chapter one and is thrown into the city by his own father. Sarene, Raoden’s sight-unseen fiancee from a political treaty, arrives in the city and gets involved in schemes, troubles, and politics involving Elantris. Hrathen, a priest and missionary, is sent to convert the people of Arelon, and is told that if he fails, the people of the country will need to be killed instead.

The three stories intertwine as the truth of what happened to Elantris, and its inhabitants, ten years ago is unearthed.